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Anti-transglutaminase IgA, serum

Test Name Anti-transglutaminase IgA, serum
Test Code ATTG
Synonyms Tissue transglutaminase antibodies (TTG)
Primarily used to screen for Celiac disease.
Collection Device/Tube Type 3.5 mL blood - gold serum separator (gel)
Submission Requirements 1 mL serum

Collection Staff:

 - Collect a separate tube for AENDO if ordered with ATTG

 - Centrifuge specimen

 - Aliquot and freeze serum before transport.

(Exception:  For patient < 2 years old, ATTG and AENDO can be done on the same specimen)
Additional Comments Physicians:

Please indicate on the requisition that the patient is IgA deficient if patient's IgA level is undetectable

Anti-endomysial antibody (AENDO):

Will automatically be done on patients < 2 years old when an ATTG is <7.0.

Will be done if the requisition states that the patient is IgA deficient.

Will be done if the patient is > 2 years old and IgA is <0.1 and ATTG is <7.0.

With the current methods, anti-transglutaminase (ATTG/TTG) has greater sensitivity for Celiac disease than anti-endomysial (AENDO/EMA),  except if the patient has low IgA levels such as in young children and patients with congenital IgA deficiency.


 Reference Ranges  


<7 Negative
7-10 Weakly positive
>10 Positive
Last Updated 21 August 2012


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